Parents in Eastwood and Kimberley are being warned to watch for symptoms of scarlet fever among their children.
Public Health England revealed there had been 134 cases of the condition reported to it in the East Midlands since the beginning of January compared with 56 in the same period last year.
More than 50 notifications in Nottinghamshire were recorded during the first eight weeks of 2014, compared with eight over the same period in 2013.
Scarlet fever is is a bacterial illness which causes a distinctive pink-red rash and affects the throat. It is most common in children aged two to eight.