Eastwood Comprehensive School got the fifth worse GCSE results in the county, the latest league table results show.
The number of pupils that got five or more A* to C grades stood at 42 per cent, Department for Education tables show.
Seven per cent of pupils at the school got the English Baccalaureate – A to C grades in maths, English, two science subjects, a language and either history or geography.
The Kimberley School did well with 63 per cent of teenagers achieving five or more top grades – higher than the national average, of 59.4 per cent.
Selston High School had 61 per cent of high achievers, and Aldercar Community Language College had 48 per cent.
The average for the whole of Nottinghamshire was 60.6 per cent – the first time the county has scored higher than the national average.
The Broxtowe borough was the second most improved district in the county. It saw a 5.2 per cent increase in the number of pupils getting high grades, compared to the previous year.
The improvement for Nottinhamshire sees it move up to 55th in the local authority league table, from 79th place last year.
Nottinghamshire County Council’s committee chairman for children and young people’s services Councillor Philip Owen said: “We need to look forward now. I believe our schools can achieve even greater things in the immediate future.
“If the rate of progress continues at this pace, over the next two years I’d like to see 70 per cent of our pupils achieving five or more A* to C grades.”
Aldercar Community Language College achieved the best A Level results in the area, followed by the Kimberley School.